Biological applications of imiquimod analogues: An update (Review)
نویسندگان
چکیده
The last decade witnessed intensive efforts in drug discovery and the emergence of thousands molecules with potential for use as therapeutic targets. However, only a few hundred these reached stage clinical trials, handful being translated from bench to bedside. One such example is imiquimod, an immune response modifier belonging imidazoquinoline family. Imiquimod was first approved by US Food Drug Administration topical treatment anal genital warts actinic keratosis, later exhibited potent antitumor activity. This promising activity inspired development several imidazoquinoxaline analogues derivatives. present review provides comprehensive overview scientific literature on chemical synthesis imiquimod its analogues, namely EAPB0203, EAPB0503 EABP02303. also discusses their preclinical properties mechanisms action context cancer parasitic infections, highlighting worthiness translating activities into drugs.
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ژورنال
عنوان ژورنال: World Academy of Sciences journal
سال: 2023
ISSN: ['2632-2900', '2632-2919']
DOI: https://doi.org/10.3892/wasj.2023.197